Magic mushrooms are known to have an extremely powerful effect on the brain. Many people who have taken them have described the experience as deeply spiritual and mystical. They have been used by humans for nearly 10,000 years and to this day people claim they can have profound effects on your mental state and alter your state of consciousness to such a degree that you feel enlightened.
Check out this awesome short video by ASAPScience which explore the chemical effects they have on your brain. This is cool.